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KMID : 0882420080750050515
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Korean Journal of Medicine
2008 Volume.75 No. 5 p.515 ~ p.524
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Genetic susceptibility factors of rheumatoid arthritis
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Lee Hye-Soon
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Abstract
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Rheumatoid arthritis (RA) is a chronic autoimmune disease that mainly involves the joints. Although the full etiology
remains unclear, both genetic and environmental factors contribute to disease. Recently, genetic studies of RA, which
include whole-genome linkage study, candidate gene association study, and especially genome-wide association study,
made much progress through the advances in technology and large collection of case-controls. These various approaches provided new susceptible genes such as PTPN22, PADI4, STAT4, TNFAIP3, TRAF1-C5, CD40 gene in addition to HLA-DRB1. This review will cover an update in recent progress in RA genetics, focusing mainly on the several novel
loci.
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KEYWORD
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Rheumatoid arthritis, Gene, Genome-wide association study
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